Fractional strong matching preclusion for two variants of hypercubes

Let F be a subset of edges and vertices of a graph G. If G-F has no fractional perfect matching, then F is a fractional strong matching preclusion set of G. The fractional strong matching preclusion number is the cardinality of a minimum fractional strong matching preclusion set. In this paper, we mainly study the fractional strong matching preclusion problem for two variants of hypercubes, the multiply twisted cube and the locally twisted cube, which are two of the most popular interconnection networks. In addition, we classify all the optimal fractional strong matching preclusion set of each

The constitutively active PKG II mutant effectively inhibits gastric cancer development a blockade of EGF/EGFR-associated signalling cascades

Type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) is a membrane-anchored enzyme expressed mainly in the intestinal mucosa and the brain, and is associated with various physiological or pathological processes. Upregulation of PKG II is known to induce apoptosis and inhibit proliferation and metastasis of cancer cells. The inhibitory effect of PKG II has been shown to be dependent on the inhibition of the activation of epidermal growth factor receptor (EGFR) and blockade of EGFR downstream signal transduction in vitro. However, it remains unclear whether similar phenomena/mechanisms exist in vivo and whether these effects are independent of cGMP or cGMP analogues. In the present work, nude mice with transplanted orthotopic tumours were infected with adenovirus encoding cDNA of constitutively active PKG II mutant (Ad-a-PKG II) and the effect of constitutively active PKG II (a-PKG II) on tumour development was detected. The results showed that a-PKG II effectively ameliorated gastric tumour development through delaying the growth, inducing the apoptosis, and inhibiting the metastasis and angiogenesis. The effect was related to blockade of EGFR activation and abrogation of the downstream signalling cascades. These findings provide novel insight which will benefit the development of new cancer therapies

Effectiveness of first and second boost COVID-19 vaccination in healthy adults during BA.5.2/BF.7 surge in China

With the development of the SARS-CoV-2 pandemic, there have been doubts about the necessity of vaccine boosters for healthy adults. However, due to the lack of relevant evidence, current research is unable to provide reliable medical advice for COVID-19 boost in healthy adults. We conducted a retrospective observational study to evaluate the effectiveness of different COVID-19 vaccination regimens by investigating the SARS-CoV-2 infection status of healthy donors in Southeast China. From December 2022 to February 2023, 737 healthy adult blood donors were analyzed. Results showed that any COVID-19 vaccine boosts reduced the risk of Omicron BA.5.2/BF.7 infection compared to only receiving prime vaccination (rVE = 16%, 95%CI = 4, 27%). The second boost further enhanced vaccine effectiveness compared to the received first booster (rVE = 39%, 95%CI = 16, 55%). Through retrospective observation of healthy adults during the BA.5.2/BF.7 surge in China, we found that boost vaccinations significantly reduce the risk of SARS-CoV-2 infection and disease. Findings show healthy adults benefit from boost vaccinations, even if not at high-risk for severe COVID-19

A One-Shot Learning, Online-Tuning, Closed-Loop Epilepsy Management SoC with 0.97uJ/Classification and 97.8% Vector-Based Sensitivity

IEEE Symposium on VLSI CircuitsUnited State

34.5 Human-Body-Coupled Power-Delivery and Ambient-Energy-Harvesting ICs for a Full-Body-Area Power Sustainability

10.1109/isscc19947.2020.90630422020 IEEE International Solid- State Circuits Conference - (ISSCC